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KMID : 0985420130350020133
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Laboratory Medicine and Quality Assurance
2013 Volume.35 No. 2 p.133 ~ p.137
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Artifactual Hyperbilirubinemia due to Paraprotein Interference in a Case of Multiple Myeloma
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Jang Jae-Yun
Kim Han-Jun
Uh Young
Kim Ju-Won
Yoon Kap-Jun
Kim Moon-Young
Kong Jee-Hyun
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Abstract
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When analyzing samples containing paraproteins, various interference effects are encountered in the clinical laboratory. Precipitation of paraproteins mostly interferes with the assays that use photometric detection. Herein, we present a case of a patient with multiple myeloma who had paraproteins and spuriously elevated total bilirubin levels (31.1 mg/dL), which were measured by using Roche total bilirubin assay on the Modular DPE (Roche Diagnostics, Switzerland) chemical analyzer. The total bilirubin concentration reduced from 31.1 mg/dL to 1.5 mg/dL, when tested after three fold dilution of the sample on Modular DPE chemical analyzer.
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KEYWORD
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Hyperbilirubinemia, Paraproteinemias, Positive bias, Chemical analyzer
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